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24-Jul-2020 22:40

We present data on the pathological complete response (p CR in breast and axilla), on clinical response using MRI, and toxicity.Addition of ZA to neoadjuvant chemotherapy did not improve pathological or clinical response to chemotherapy.Two recent meta-analysis showed benefit of adjuvant BPs. concluded that overall adjuvant ZA did not result in better outcome in all BC patients, but that it provides better disease-free survival (DFS) and reduced risk of recurrences in postmenopausal patients [11–14] and in a meta-analysis with individual patient data from a group of 20 000 patients. revealed a beneficial effect of the addition of BPs to adjuvant therapy on BC death and bone recurrence [15].In the neoadjuvant setting, a retrospective evaluation of a subpopulation of patients ( = 205) treated with neoadjuvant chemotherapy in the AZURE study, which evaluated the effect of chemotherapy and/or hormone therapy with or without ZA in treating women with stage II/III BC, has shown a significant improvement in pathological complete response (p CR) of 10.9% versus 5.8% when therapy was complemented with ZA [16]. I'm Elizabeth Sears, but all my friends call me Teeter! If you or someone you know has Apert Syndrome like me, or if you have any questions, we would love to hear from you! If you are able to help financially, please visit our charity website at No amount is too small, and every donation will be gratefully accepted and acknowledged.The aim of our current prospective randomized study, was to investigate in a homogenous study population the efficacy of neoadjuvant chemotherapy (TAC; docetaxel, adriamycin, and cyclofosfamide) with ZA in patients with stage II or III BC.

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One of the proposed mechanisms for the antitumor effect of BPs is a modulatory effect on the bone microenvironment, by inhibition of secretion of tumor-stimulating growth factors released during bone turnover [1, 2].



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